I can’t imagine E=MC^2 being wrong – it derives mathematically from the 2nd law off motion. Yes the one that Bart said was superceded by relativity. – http://www.btinternet.com/~j.doyle/SR/Emc2/Deriving.htm – You would tend to question the experimental results instead.
2 + 2 I can imagine being wrong if the math is nonlinear.
A hand is five.
the other is five.
So what do you get when
you add five plus five?
A butterfly.
Do you get the distinction? One is a universal physical law – the other is dependent on ititial conditions.